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Error threshold (evolution)
In evolutionary biology and population genetics, the error threshold (or critical mutation rate) is a limit on the number of base pairs a self-replicating molecule may have before mutation will destroy the information in subsequent generations of the molecule. The error threshold is crucial to understanding "Eigen's paradox".
The error threshold is a concept in the origins of life (abiogenesis), in particular of very early life, before the advent of DNA. It is postulated that the first self-replicating molecules might have been small ribozyme-like RNA molecules. These molecules consist of strings of base pairs or "digits", and their order is a code that directs how the molecule interacts with its environment. All replication is subject to mutation error. During the replication process, each digit has a certain probability of being replaced by some other digit, which changes the way the molecule interacts with its environment, and may increase or decrease its fitness, or ability to reproduce, in that environment.
== Fitness landscape ==
(詳細はManfred Eigen in his 1971 paper (Eigen 1971) that this mutation process places a limit on the number of digits a molecule may have. If a molecule exceeds this critical size, the effect of the mutations become overwhelming and a runaway mutation process will destroy the information in subsequent generations of the molecule. The error threshold is also controlled by the fitness landscape for the molecules. Molecules that differ only by a few mutations may be thought of as "close" to each other, while those that differ by many mutations are distant from each other. Molecules that are very fit, and likely to reproduce, have a "high" fitness, those less fit have "low" fitness.
These ideas of proximity and height form the intuitive concept of the "fitness landscape". If a particular sequence and its neighbors have a high fitness, they will form a quasispecies and will be able to support longer sequence lengths than a fit sequence with few fit neighbors, or a less fit neighborhood of sequences. Also, it was noted by Wilke (Wilke 2005) that the error threshold concept does not apply in portions of the landscape where there are lethal mutations, in which the induced mutation yields zero fitness and prohibits the molecule from reproducing.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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